Phenotypes associated with this allele

• Allele Symbol: Nnat^tm1.2Geno
• Allele Name: targeted mutation 1.2, Genoway
• Allele ID: MGI:6455186
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nnat^tm1.2Geno/Nnat^+	either: 129S2(Cg)-Nnat^tm1.2Geno or B6.129S2(Cg)-Nnat^tm1.2Geno	MGI:6715255

Genotype
MGI:6715255

ht1

• Allelic Composition: Nnat^tm1.2Geno/Nnat⁺
• Genetic Background: either: 129S2(Cg)-Nnat^tm1.2Geno or B6.129S2(Cg)-Nnat^tm1.2Geno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

maternal imprinting ( J:265677 )

• locus is maternally imprinted with no gene expression detectable in mice that have paternally inherited the mutant allele

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:265677 )

• primary islets from mice with the paternally inherited allele exhibit reduced mature insulin content and proinsulin content, indicating a defect in insulin storage

abnormal pancreatic beta cell morphology ( J:265677 )

• beta cells from mice with the paternally inherited allele show a reduction of mature insulin-containing dense core secretory granules, and an increased proportion of partially filled, or empty granules

decreased insulin secretion ( J:265677 )

♂ • males with the paternally inherited allele exhibit impaired glucose-stimulated insulin secretion, with complete absence of an increase from basal insulin levels

♂ • pancreatic beta cells from mice with the paternally inherited allele show a smaller increase in insulin secretion with high glucose compared to wild-type cells

homeostasis/metabolism

decreased insulin secretion ( J:265677 )

♂ • males with the paternally inherited allele exhibit impaired glucose-stimulated insulin secretion, with complete absence of an increase from basal insulin levels

♂ • pancreatic beta cells from mice with the paternally inherited allele show a smaller increase in insulin secretion with high glucose compared to wild-type cells

increased circulating insulin level ( J:265677 )

♂ • males with the paternally inherited allele exhibit basal hyperinsulinemia

growth/size/body

growth/size/body region phenotype ( J:265677 )

♂N • males with the paternally inherited allele show unaltered body weight

behavior/neurological

behavior/neurological phenotype ( J:265677 )

♂N • males with the paternally inherited allele show unaltered feeding behavior