Phenotypes associated with this allele

• Allele Symbol: Rbm14^em1Wli
• Allele Name: endonuclease-mediated mutation 1, Wei Li
• Allele ID: MGI:6455488
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbm14^em1Wli/Rbm14^em1Wli	involves: ICR	MGI:6455490

Genotype
MGI:6455490

hm1

• Allelic Composition: Rbm14^em1Wli/Rbm14^em1Wli
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:290444 )

• no mice are produced from breeding heterozygous mice

embryo

failure to gastrulate ( J:290444 )

• disruption at early gastrulation stage

• absence of late gastrulation stage structures at E7.5

abnormal embryonic epiblast morphology ( J:290444 )

• reduced cell density

abnormal primitive streak morphology ( J:290444 )

• absent primitive streak

absent allantois ( J:290444 )

absent amnion ( J:290444 )

absent chorion ( J:290444 )

abnormal extraembryonic mesoderm development ( J:290444 )

• reduced cell density in the embryonic mesoderm

abnormal visceral endoderm morphology ( J:290444 )

• cells are piled up in visceral endoderm

cellular

abnormal cell cycle ( J:290444 )

• cell cycle arrest in post-implantation epiblast

increased apoptosis ( J:290444 )

• in post-implantation epiblast