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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Coq8btm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:6455494
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Coq8btm1c(EUCOMM)Hmgu/Coq8btm1c(EUCOMM)Hmgu
Tg(NPHS2-cre)295Lbh/0
involves: C3H * C57BL/6 * C57BL/6N * SJL MGI:6455521


Genotype
MGI:6455521
cn1
Allelic
Composition
Coq8btm1c(EUCOMM)Hmgu/Coq8btm1c(EUCOMM)Hmgu
Tg(NPHS2-cre)295Lbh/0
Genetic
Background
involves: C3H * C57BL/6 * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq8btm1c(EUCOMM)Hmgu mutation (0 available); any Coq8b mutation (30 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• from age 9 months

cellular
• in glomerular podocytes as mice age 10 months
• in glomerular podocytes as mice age 10 months

homeostasis/metabolism
• from age 7 months
• increase in creatinine-albumin ratio from age 5 months
• from age 5 months
• increase in creatinine-albumin ratio from age 5 months
• increase in creatinine-albumin ratio from age 5 months

integument
• seedy fur from age 9 months

mortality/aging
• from age 9 months

renal/urinary system
• at age 10 months
• significantly reduced number of filtration-slit units per micrometer of basement membrane at age 10 months
• global and focal segmental glomerulosclerosis at age 10 months
• at age 10 months
• at age 10 months
• at age 10 months
• at age 10 months





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory