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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir149em1Ydw
endonuclease-mediated mutation 1, Yan-Dong Wang
MGI:6455680
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir149em1Ydw/Mir149em1Ydw C57BL/6J-Mir149em1Ydw MGI:6455684


Genotype
MGI:6455684
hm1
Allelic
Composition		 Mir149em1Ydw/Mir149em1Ydw
Genetic
Background		 C57BL/6J-Mir149em1Ydw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir149em1Ydw mutation (0 available); any Mir149 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte apoptosis ( J:294318 )
• in LPS-treated mice
increased hepatocyte proliferation ( J:294318 )
• prior to and after LPS-treatment

immune system
increased susceptibility to endotoxin shock ( J:294318 )
• mice treated with LPS exhibit increased inflammation and injury (as measured by increased AST levels, hepatocyte apoptosis, and hepatocyte proliferation) compared with wild-type mice

homeostasis/metabolism

cellular
increased hepatocyte apoptosis ( J:294318 )
• in LPS-treated mice
increased hepatocyte proliferation ( J:294318 )
• prior to and after LPS-treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory