All Phenotypes Skp1<tm1.2Jw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Skp1^tm1.2Jw
targeted mutation 1.2, Jeremy Wang
MGI:6455735

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Skp1^tm1.1Jw/Skp1^tm1.2Jw Tg(Ddx4-cre)1Dcas/0	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:6455745
cn2	Skp1^tm1.1Jw/Skp1^tm1.2Jw Tg(Ddx4-cre/ERT2)1Dcas/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:6455746

Allelic Composition	Skp1^tm1.1Jw/Skp1^tm1.2Jw Tg(Ddx4-cre)1Dcas/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skp1^tm1.1Jw mutation (0 available); any Skp1 mutation (18 available)
Skp1^tm1.2Jw mutation (0 available); any Skp1 mutation (18 available)
Tg(Ddx4-cre)1Dcas mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

absent germ cells ( J:289957 )

reproductive system

absent germ cells ( J:289957 )

Allelic Composition	Skp1^tm1.1Jw/Skp1^tm1.2Jw Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skp1^tm1.1Jw mutation (0 available); any Skp1 mutation (18 available)
Skp1^tm1.2Jw mutation (0 available); any Skp1 mutation (18 available)
Tg(Ddx4-cre/ERT2)1Dcas mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oocyte degeneration ( J:289957 )

• at 4 months in tamoxifen-treated mice despite being present at 2 months

abnormal chromosomal synapsis ( J:289957 )

• precocious chromosomal desynapsis in the female and male germ cells of tamoxifen-treated mice

abnormal female meiosis ( J:289957 )

• misalignment of chromosomes in the oocytes of tamoxifen treated mice

decreased testis weight ( J:289957 )

• progressive in tamoxifen-treated mice

abnormal spermatogenesis ( J:289957 )

• severe in tamoxifen-treated mice with absent metaphase spermatocytes

azoospermia ( J:289957 )

• absent metaphase spermatocytes and postmeiotic spermatids in tamoxifen-treated mice

arrest of male meiosis ( J:289957 )

• precocious chromosomal desynapsis and pachytene exit leading to absent metaphase spermatocytes in tamoxifen-treated mice

female infertility ( J:289957 )

• in tamoxifen-treated mice

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:289957 )

• impaired meiotic recombination in spermatocytes and oocytes of tamoxifen-treated mice

endocrine/exocrine glands

decreased testis weight ( J:289957 )

• progressive in tamoxifen-treated mice

cellular

oocyte degeneration ( J:289957 )

• at 4 months in tamoxifen-treated mice despite being present at 2 months

azoospermia ( J:289957 )

• absent metaphase spermatocytes and postmeiotic spermatids in tamoxifen-treated mice

abnormal chromosomal synapsis ( J:289957 )

• precocious chromosomal desynapsis in the female and male germ cells of tamoxifen-treated mice

abnormal female meiosis ( J:289957 )

• misalignment of chromosomes in the oocytes of tamoxifen treated mice

arrest of male meiosis ( J:289957 )

• precocious chromosomal desynapsis and pachytene exit leading to absent metaphase spermatocytes in tamoxifen-treated mice

abnormal double-strand DNA break repair ( J:289957 )

• impaired meiotic recombination in spermatocytes and oocytes of tamoxifen-treated mice

maternal effect ( J:289957 )

• in vitro fertilized oocytes fail to sustain preimplantation embryonic development

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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