Phenotypes associated with this allele

• Allele Symbol: Lrrc8e^em1Bcgen
• Allele Name: endonuclease-mediated mutation 1, Biocytogen LLC
• Allele ID: MGI:6456566
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrc8e^em1Bcgen/Lrrc8e^em1Bcgen	C57BL/6N-Lrrc8e^em1Bcgen	MGI:6456577

Genotype
MGI:6456577

hm1

• Allelic Composition: Lrrc8e^em1Bcgen/Lrrc8e^em1Bcgen
• Genetic Background: C57BL/6N-Lrrc8e^em1Bcgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to viral infection induced morbidity/mortality ( J:288504 )

• in HSV-1-infected mice

immune system

abnormal circulating cytokine level ( J:288504 )

• HSV-1-infected mice exhibit reduced IFN-beta, CXCL-5, CCL-5, and TNF response compared with wild-type mice

decreased circulating interferon-beta level ( J:288504 )

• in HSV-1-infected mice

decreased circulating tumor necrosis factor level ( J:288504 )

• in HSV-1-infected mice

decreased interferon-beta secretion ( J:288504 )

• in HSV-1 exposed bone marrow-derived macrophages

• however, mice exhibit normal response to VSV infection

increased susceptibility to viral infection ( J:288504 )

• mouse lung fibroblasts exposed to HSV-1 exhibit increased viral replication compared with control mice

increased susceptibility to viral infection induced morbidity/mortality ( J:288504 )

• in HSV-1-infected mice

growth/size/body

increased susceptibility to weight loss ( J:288504 )

• in HSV-1-infected mice

homeostasis/metabolism

abnormal circulating cytokine level ( J:288504 )

• HSV-1-infected mice exhibit reduced IFN-beta, CXCL-5, CCL-5, and TNF response compared with wild-type mice

decreased circulating interferon-beta level ( J:288504 )

• in HSV-1-infected mice

decreased circulating tumor necrosis factor level ( J:288504 )

• in HSV-1-infected mice