Phenotypes associated with this allele

• Allele Symbol: Rbm7^em1Aki
• Allele Name: endonuclease-mediated mutation 1, Shizuo Akira
• Allele ID: MGI:6456581
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbm7^em1Aki/Rbm7^em1Aki	B6.Cg-Rbm7^em1Aki	MGI:6456607

Genotype
MGI:6456607

hm1

• Allelic Composition: Rbm7^em1Aki/Rbm7^em1Aki
• Genetic Background: B6.Cg-Rbm7^em1Aki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:288329 )

• bleomycin-treated mice exhibit less collagen and alpha-smooth muscle actin deposition in the lungs and reduced numbers of segregated-nucleus-containing atypical monocytes compared with wild-type mice

• mice exhibit reduced liver fibrosis induced by a choline-deficient, L-amino acid-defined, high-fat diet (CDA-HFD) along with reduced cell death compared with wild-type mice mice subjected to unilateral ureteral obstruction exhibit reduced fibrosis along with reduced cell death compared with wild-type mice

• however, CDA-HFD-induced liver steatosis is normal

immune system

decreased monocyte cell number ( J:288329 )

• reduced numbers of segregated-nucleus-containing atypical monocytes in bleomycin-treated mice

renal/urinary system

renal fibrosis ( J:288329 )

• mice subjected to unilateral ureteral obstruction exhibit reduced fibrosis compared with wild-type mice

liver/biliary system

liver fibrosis ( J:288329 )

• reduced liver fibrosis induced by a choline-deficient, L-amino acid-defined, high-fat diet

respiratory system

pulmonary fibrosis ( J:288329 )

• bleomycin-treated mice exhibit less collagen and alpha-smooth muscle actin deposition in the lungs compared with wild-type mice

hematopoietic system

decreased monocyte cell number ( J:288329 )

• reduced numbers of segregated-nucleus-containing atypical monocytes in bleomycin-treated mice