Phenotypes associated with this allele

• Allele Symbol: Ralgapa1^tm1.1Schen
• Allele Name: targeted mutation 1.1, Shuai Chen
• Allele ID: MGI:6456667
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ralgapa1^tm1.1Schen/Ralgapa1^tm1.1Schen	involves: C57BL/6J	MGI:6456688

Genotype
MGI:6456688

hm1

• Allelic Composition: Ralgapa1^tm1.1Schen/Ralgapa1^tm1.1Schen
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased fasting circulating glucose level ( J:287672 )

• around 6 months

increased circulating insulin level ( J:287672 )

• around 6 months

increased circulating cholesterol level ( J:287672 )

• in young and molder mice

increased circulating free fatty acids level ( J:287672 )

• in young mice

increased circulating triglyceride level ( J:287672 )

• in young and older mice

insulin resistance ( J:287672 )

• in younger and older mice when fed a bolus of glucose and intraperitoneally injected with insulin

increased liver cholesterol level ( J:287672 )

• in older mice

increased liver triglyceride level ( J:287672 )

• in older mice

• in mice challenged with olive oil

adipose tissue

increased total body fat amount ( J:287672 )

• from around 5.5 months

increased fat cell size ( J:287672 )

muscle

abnormal muscle physiology ( J:287672 )

• insulin-stimulated lipid uptake and oxidation are inhibited compared to in wild-type mice

decreased muscle cell glucose uptake ( J:287672 )

• insulin-stimulated

growth/size/body

increased body weight ( J:287672 )

• from 10 weeks of age onward

cellular

decreased muscle cell glucose uptake ( J:287672 )

• insulin-stimulated

liver/biliary system

increased liver cholesterol level ( J:287672 )

• in older mice

increased liver triglyceride level ( J:287672 )

• in older mice

• in mice challenged with olive oil