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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Brme1em1Hirok
endonuclease-mediated mutation 1, Hiroki Shibuya
MGI:6456788
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Brme1em1Hirok/Brme1em1Hirok C57BL/6J-Brme1em1Hirok MGI:6456828


Genotype
MGI:6456828
hm1
Allelic
Composition		 Brme1em1Hirok/Brme1em1Hirok
Genetic
Background		 C57BL/6J-Brme1em1Hirok
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brme1em1Hirok mutation (0 available); any Brme1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:292036 )
• spermatids absent from testes, mature sperm absent from epididymis
abnormal chiasmata formation ( J:292036 )
• misaligned univalent chromosomes in metaphase I spermatocytes
abnormal chromosomal synapsis ( J:292036 )
• autosomal asynapsis in pachytene spermatocytes
• non-homologous synapsis in spermatocytes
• univalent short autosomal chromosomes in spermatocytes
abnormal male meiosis ( J:292036 )
• significant accumulation of early prophase I (leptotene and zygotene) and reduction of late prophase I (diplotene and metaphase I) spermatocyte populations
abnormal X-Y chromosome synapsis during male meiosis ( J:292036 )
• sex chromosome asynapsis in pachytene spermatocytes
• sex chromosome excessive synapsis (outside PAR) in pachytene spermatocytes
• univalent sex chromosomes in spermatocytes
increased male germ cell apoptosis ( J:292036 )
• in prophase I and metaphase I spermatocytes in seminiferous tubules at stage XII

cellular
azoospermia ( J:292036 )
• spermatids absent from testes, mature sperm absent from epididymis
abnormal chiasmata formation ( J:292036 )
• misaligned univalent chromosomes in metaphase I spermatocytes
abnormal chromosomal synapsis ( J:292036 )
• autosomal asynapsis in pachytene spermatocytes
• non-homologous synapsis in spermatocytes
• univalent short autosomal chromosomes in spermatocytes
abnormal male meiosis ( J:292036 )
• significant accumulation of early prophase I (leptotene and zygotene) and reduction of late prophase I (diplotene and metaphase I) spermatocyte populations
abnormal X-Y chromosome synapsis during male meiosis ( J:292036 )
• sex chromosome asynapsis in pachytene spermatocytes
• sex chromosome excessive synapsis (outside PAR) in pachytene spermatocytes
• univalent sex chromosomes in spermatocytes
increased male germ cell apoptosis ( J:292036 )
• in prophase I and metaphase I spermatocytes in seminiferous tubules at stage XII
abnormal double-strand DNA break repair ( J:292036 )
• unrepaired DSBs persist until late prophase I in spermatocytes
• reduced intensity of BRCA2, RAD1 and DMC1 punctuate foci at DSBs in spermatocytes
• increased intensity of SPATA22 punctuate foci at DSBs in spermatocytes

endocrine/exocrine glands

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:292036 )
• unrepaired DSBs persist until late prophase I in spermatocytes
• reduced intensity of BRCA2, RAD1 and DMC1 punctuate foci at DSBs in spermatocytes
• increased intensity of SPATA22 punctuate foci at DSBs in spermatocytes




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory