About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Brme1em1Hirok
endonuclease-mediated mutation 1, Hiroki Shibuya
MGI:6456788
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Brme1em1Hirok/Brme1em1Hirok C57BL/6J-Brme1em1Hirok MGI:6456828


Genotype
MGI:6456828
hm1
Allelic
Composition		 Brme1em1Hirok/Brme1em1Hirok
Genetic
Background		 C57BL/6J-Brme1em1Hirok
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brme1em1Hirok mutation (0 available); any Brme1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:292036 )
• spermatids absent from testes, mature sperm absent from epididymis
abnormal chiasmata formation ( J:292036 )
• misaligned univalent chromosomes in metaphase I spermatocytes
abnormal chromosomal synapsis ( J:292036 )
• autosomal asynapsis in pachytene spermatocytes
• non-homologous synapsis in spermatocytes
• univalent short autosomal chromosomes in spermatocytes
abnormal male meiosis ( J:292036 )
• significant accumulation of early prophase I (leptotene and zygotene) and reduction of late prophase I (diplotene and metaphase I) spermatocyte populations
abnormal X-Y chromosome synapsis during male meiosis ( J:292036 )
• sex chromosome asynapsis in pachytene spermatocytes
• sex chromosome excessive synapsis (outside PAR) in pachytene spermatocytes
• univalent sex chromosomes in spermatocytes
increased male germ cell apoptosis ( J:292036 )
• in prophase I and metaphase I spermatocytes in seminiferous tubules at stage XII

cellular
azoospermia ( J:292036 )
• spermatids absent from testes, mature sperm absent from epididymis
abnormal chiasmata formation ( J:292036 )
• misaligned univalent chromosomes in metaphase I spermatocytes
abnormal chromosomal synapsis ( J:292036 )
• autosomal asynapsis in pachytene spermatocytes
• non-homologous synapsis in spermatocytes
• univalent short autosomal chromosomes in spermatocytes
abnormal male meiosis ( J:292036 )
• significant accumulation of early prophase I (leptotene and zygotene) and reduction of late prophase I (diplotene and metaphase I) spermatocyte populations
abnormal X-Y chromosome synapsis during male meiosis ( J:292036 )
• sex chromosome asynapsis in pachytene spermatocytes
• sex chromosome excessive synapsis (outside PAR) in pachytene spermatocytes
• univalent sex chromosomes in spermatocytes
increased male germ cell apoptosis ( J:292036 )
• in prophase I and metaphase I spermatocytes in seminiferous tubules at stage XII
abnormal double-strand DNA break repair ( J:292036 )
• unrepaired DSBs persist until late prophase I in spermatocytes
• reduced intensity of BRCA2, RAD1 and DMC1 punctuate foci at DSBs in spermatocytes
• increased intensity of SPATA22 punctuate foci at DSBs in spermatocytes

endocrine/exocrine glands

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:292036 )
• unrepaired DSBs persist until late prophase I in spermatocytes
• reduced intensity of BRCA2, RAD1 and DMC1 punctuate foci at DSBs in spermatocytes
• increased intensity of SPATA22 punctuate foci at DSBs in spermatocytes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory