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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igs2em5(CAG-Mir802)Gpt
endonuclease-mediated mutation 5, GemPharmatech Co., Ltd
MGI:6456816
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Igs2em5(CAG-Mir802)Gpt/Igs2em5(CAG-Mir802)Gpt
Tg(Ins2-cre)25Mgn/0 		involves: C57BL/6JGpt * DBA MGI:6456820


Genotype
MGI:6456820
cn1
Allelic
Composition		 Igs2em5(CAG-Mir802)Gpt/Igs2em5(CAG-Mir802)Gpt
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: C57BL/6JGpt * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2em5(CAG-Mir802)Gpt mutation (0 available); any Igs2 mutation (82 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased insulin secretion ( J:287584 )
• following exposure to glucose or 35 mM KCl
decreased circulating insulin level ( J:287584 )
• in mice after glucose injection
impaired glucose tolerance ( J:287584 )
• in mice challenged with IPGTT
• in islet cells exposed to glucose or 35 mM KCl

endocrine/exocrine glands
abnormal pancreatic beta cell differentiation ( J:287584 )
• reduced beta-cell differentiation as determined by marker expression
decreased insulin secretion ( J:287584 )
• following exposure to glucose or 35 mM KCl

cellular
abnormal pancreatic beta cell differentiation ( J:287584 )
• reduced beta-cell differentiation as determined by marker expression




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Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory