Phenotypes associated with this allele

• Allele Symbol: Chd3^tm1.1Cya
• Allele Name: targeted mutation 1.1, Cyagen Biosciences
• Allele ID: MGI:6456882
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chd3^tm1.1Cya/Chd3^tm1.1Cya Edil3^Tg(Sox2-cre)1Amc/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:6456931
cn2	Chd3^tm1.1Cya/Chd3^tm1.1Cya Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:6456932
cn3	Chd3^tm1.1Cya/Chd3^tm1.1Cya Chd4^tm1.1Kge/Chd4^tm1.1Kge Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:6456933

Genotype
MGI:6456931

cn1

• Allelic Composition: Chd3^tm1.1Cya/Chd3^tm1.1Cya; Edil3^{Tg(Sox2-cre)1Amc}/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:294633 )

• fewer than expected homozygous offspring are born

reproductive system

reproductive system phenotype ( J:294633 )

N • fertile

Genotype
MGI:6456932

cn2

• Allelic Composition: Chd3^tm1.1Cya/Chd3^tm1.1Cya; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

cardiovascular system

cardiovascular system phenotype ( J:294633 )

N • normal embryonic vasculature

abnormal blood vessel morphology ( J:294633 )

• no obvious anomalies

mortality/aging

mortality/aging ( J:294633 )

N • viable; mice born at expected Mendelian ratio

Genotype
MGI:6456933

cn3

• Allelic Composition: Chd3^tm1.1Cya/Chd3^tm1.1Cya; Chd4^tm1.1Kge/Chd4^tm1.1Kge; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

cardiovascular system

abnormal blood vessel morphology ( J:294633 )

• vascular rupture in E11.5 embryos

• normal vasculature in E10.5 embryos

hemorrhage ( J:294633 )

• in E11.5 embryos

mortality/aging

embryonic lethality, complete penetrance ( J:294633 )

• most embryos die between age E10.5-11.5