All Phenotypes Tg(Thy1/THY1)T12Gsv MGI Mouse

increased urine protein level ( J:133943 )

• all mice develop proteinuria after the first month

abnormal podocyte foot process morphology ( J:133943 )

• mice show minor degrees of prodocyte foot process swelling at 36 days of age

• severely damaged glomeruli have podocyte abnormalities with foot process swelling and vacuolation

podocyte vacuoles ( J:133943 )

• podocyte vacuolization is seen in severely damaged glomeruli

abnormal renal glomerulus morphology ( J:133943 )

• mice show extensive glomerular changes with increasing severity of proteinuria

• glomerular tubules become dilated and contain protein casts

• changes in the glomerulus vary from glomerulus to glomerulus, with some showing areas of lobular collapse and increase of basement membrane-like material and others having electron dense deposits mostly in the mesangium

• however, extracapillary proliferation and subepithelial deposits are not seen

abnormal glomerular mesangium morphology ( J:133943 )

• severely damaged glomeruli show heavy deposits of IgG, IgM, and C3 in the mesangial regions

glomerulosclerosis ( J:133943 )

• glomerular change looks like severe segmental sclerosis

abnormal renal tubule morphology ( J:133943 )

• mice show extensive tubular changes with increasing severity of proteinuria

granular kidney ( J:133943 )

• severe kidney sclerosis

kidney failure ( J:133943 )

increased IgG level ( J:133943 )

• heavy deposits of IgG are seen in severely damaged glomeruli

increased IgM level ( J:133943 )

• heavy deposits of IgM are seen in severely damaged glomeruli