mortality/aging
neoplasm
• brain of one mouse shows a papillomatous neoplasm of the choroid plexus that fills the third and fourth ventricles; cells show cytological atypia
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• mice develop cystic neoplasms in the kidney derived from the proximal tubules through an intermediate in situ tumor
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renal/urinary system
• mice develop cystic neoplasms in the kidney derived from the proximal tubules through an intermediate in situ tumor
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• in some tubules, the epithelial cells show nuclear variability, and increase in nuclear size, and a high mitotic rate, leading to closure of the tubules
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