Phenotypes associated with this allele

• Allele Symbol: Tpte^tm1Osb
• Allele Name: targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:6458829
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpte^tm1Osb/Tpte^tm1Osb	involves: C57BL/6N	MGI:6458888

Genotype
MGI:6458888

hm1

• Allelic Composition: Tpte^tm1Osb/Tpte^tm1Osb
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm midpiece morphology ( J:282803 )

• loss of flexibility

impaired fertilization ( J:282803 )

• despite normal sperm morphology, acrosome reaction, and capacitation

abnormal sperm physiology ( J:282803 )

• enhanced calcium response in tails, but not heads, that is mediated by altered Slo3 activity

asthenozoospermia ( J:282803 )

• sperm exhibit reduced average path velocity, curvilinear velocity, straight-line velocity, straightness, and linearity compared with wild-type sperm

• however, incubation in low calcium conditions reduces abnormal motility

cellular

abnormal sperm midpiece morphology ( J:282803 )

• loss of flexibility

asthenozoospermia ( J:282803 )

• sperm exhibit reduced average path velocity, curvilinear velocity, straight-line velocity, straightness, and linearity compared with wild-type sperm

• however, incubation in low calcium conditions reduces abnormal motility