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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cc2d1atm1.1Thkn
targeted mutation 1.1, Thomas Klein
MGI:6458916
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cc2d1atm1.1Thkn/Cc2d1atm1.1Thkn involves: 129S4/SvJae * C57BL/6 * SJL MGI:6459278
cn2
 		Cc2d1atm1.1Thkn/Cc2d1atm1.1Thkn
Hes1tm1.1Sat/Hes1+
Tg(Vil1-cre)997Gum/0 		involves: 129S4/SvJae * C57BL/6NTac * SJL MGI:6459274
cn3
 		Cc2d1atm1.1Thkn/Cc2d1atm1.1Thkn
Tg(Vil1-cre)997Gum/0 		involves: 129S4/SvJae * C57BL/6 * SJL MGI:6459275
cn4
 		Cc2d1atm1.1Thkn/Cc2d1atm1.1Thkn
Tg(Nes-cre)1Kln/0 		involves: 129S4/SvJae * C57BL/6 * SJL MGI:6459277


Genotype
MGI:6459278
hm1
Allelic
Composition		 Cc2d1atm1.1Thkn/Cc2d1atm1.1Thkn
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cc2d1atm1.1Thkn mutation (0 available); any Cc2d1a mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:236761 )
• mice are viable, fertile and do not display any obvious phenotype




Genotype
MGI:6459274
cn2
Allelic
Composition		 Cc2d1atm1.1Thkn/Cc2d1atm1.1Thkn
Hes1tm1.1Sat/Hes1+
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cc2d1atm1.1Thkn mutation (0 available); any Cc2d1a mutation (32 available)
Hes1tm1.1Sat mutation (0 available); any Hes1 mutation (23 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:236761 )
N
• mice exhibit normal intestinal Notch signaling




Genotype
MGI:6459275
cn3
Allelic
Composition		 Cc2d1atm1.1Thkn/Cc2d1atm1.1Thkn
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cc2d1atm1.1Thkn mutation (0 available); any Cc2d1a mutation (32 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:236761 )
N
• mice exhibit normal intestine morphology




Genotype
MGI:6459277
cn4
Allelic
Composition		 Cc2d1atm1.1Thkn/Cc2d1atm1.1Thkn
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cc2d1atm1.1Thkn mutation (0 available); any Cc2d1a mutation (32 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:236761 )
• Background Sensitivity: all mice on a mixed background die within 12 hours of birth compared with mice on a background with increased C57BL/6 that die at birth

respiratory system
respiratory distress ( J:236761 )
• severe in 4 of 12 mice at birth

homeostasis/metabolism
cyanosis ( J:236761 )
• Background Sensitivity: in 4 of 12 mice on a mixed background at birth compared with 5 of 5 mice on a background with increased C57BL/6




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory