Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-ACE2)2Rbre
• Allele Name: transgene insertion 2, Roger E Breitbart
• Allele ID: MGI:6459903
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-ACE2)2Rbre/0	involves: FVB/N	MGI:6459905

Genotype
MGI:6459905

tg1

• Allelic Composition: Tg(Myh6-ACE2)2Rbre/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:128793 )

• approximate 30% long-term survival

premature death ( J:128793 )

• 50% of mice die by 5 weeks of age

cardiovascular system

abnormal myocardial fiber morphology ( J:128793 )

• hearts show rare focal myocyte vacuolization, myofibril splaying, and nuclear enlargement

cardiac interstitial fibrosis ( J:128793 )

• hearts show mild focal interstitial fibrosis

• however, hearts are grossly normal without hypertrophy or chamber enlargement, normal ventricular myocardium

ventricular tachycardia ( J:128793 )

• 4-week old mice exhibit non-sustained and sustained ventricular tachycardia

• ventricular tachycardia is initiated after prolonged ventricular pause (following a ventricular premature beat or A-V block) and shows no circadian or activity-related correlation

• programmed stimulation induces ventricular tachycardia in 63% of transgenic mice with none in wild-type mice

• 5 week old mice show no differences in ventricular tachycardia frequency before, during, or after exercise

ventricular fibrillation ( J:128793 )

• 4 of 12 mice that die suddenly show ventricular tachycardia progressing to ventricular fibrillation

ventricular premature beat ( J:128793 )

• 3 of 8 mice exhibit ventricular premature beats at 3 weeks of age

• all mice show high-grade ventricular ectopy at 4 weeks of age

• ventricular premature beat density increases at slower heart rates associated with high-grade atrioventricular block

• however, beginning at 5 weeks of age, the surviving mice show decreased ventricular ectopy density

• 5 week old mice show no differences in ventricular premature beat before, during, or after exercise

• isoproterenol or atropine treatment reduces ventricular premature beat frequency

abnormal atrioventricular bundle conduction ( J:128793 )

• all mice at 3 weeks of age exhibit complete atrial-His (AH) block

• by 6-9 months of age, surviving mice have one-to-one A-V conduction, albeit with prolonged AH and AV node-effective refractory periods

atrioventricular block ( J:128793 )

• all mice develop first-degree atrioventricular (AV) block by 2 weeks of age

• by 3 weeks, all mice progress to complete atrioventricular block

• however, beginning at 5 weeks of age, the surviving mice show improved atrioventricular conduction

prolonged PR interval ( J:128793 )

• all mice exhibit prolonged PR at 2 weeks of age

abnormal heart electrocardiography waveform feature ( J:128793 )

• mice at 3 weeks of age exhibit increased atrial-effective refractory period and ventricular-effective refractory period

prolonged HV interval ( J:128793 )

• all mice at 3 weeks of age exhibit prolonged His-ventricular intervals

prolonged QRS complex duration ( J:128793 )

• all mice show mild QRS prolongation at 2 weeks of age

decreased mean systemic arterial blood pressure ( J:128793 )

• lower mean arterial blood pressure at baseline and throughout the dobutamine dose range

liver/biliary system

focal hepatic necrosis ( J:128793 )

• focal apoptosis and necrosis in centrilobular areas of the liver

muscle

abnormal myocardial fiber morphology ( J:128793 )

• hearts show rare focal myocyte vacuolization, myofibril splaying, and nuclear enlargement

nervous system

abnormal hippocampus morphology ( J:128793 )

• focal apoptosis and necrosis in CA1/CA2 regions of the hippocampus

cellular

cardiac interstitial fibrosis ( J:128793 )

• hearts show mild focal interstitial fibrosis

• however, hearts are grossly normal without hypertrophy or chamber enlargement, normal ventricular myocardium