Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(CARD14*)Ribt}
• Allele Name: targeted mutation 1, Rudi Beyaert
• Allele ID: MGI:6459917
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(CARD14*)Ribt/Gt(ROSA)26Sor^+ Tg(KRT5-cre)5132Jlj/0	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * DBA/2J	MGI:6460069
cn2	Gt(ROSA)26Sor^tm1(CARD14*)Ribt/Gt(ROSA)26Sor^+ Malt1^tm1c(EUCOMM)Hmgu/Malt1^tm1c(EUCOMM)Hmgu Tg(KRT5-cre)5132Jlj/0	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * DBA/2J	MGI:6460070
cn3	Gt(ROSA)26Sor^tm1(CARD14*)Ribt/Gt(ROSA)26Sor^+ Tg(KRT14-cre/ERT)20Efu/0	involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1	MGI:6460073
cn4	Gt(ROSA)26Sor^tm1(CARD14*)Ribt/Gt(ROSA)26Sor^+ Malt1^tm1c(EUCOMM)Hmgu/Malt1^tm1c(EUCOMM)Hmgu Tg(KRT14-cre/ERT)20Efu/0	involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1	MGI:6460074

Genotype
MGI:6460069

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CARD14*)Ribt}/Gt(ROSA)26Sor⁺; Tg(KRT5-cre)5132Jlj/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:292094 )

• mice delivered by Caesarian section do not survive beyond 24 hours after birth

integument

integument phenotype ( J:292094 )

N • mice exhibit normal epidermal skin barrier function

Genotype
MGI:6460070

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CARD14*)Ribt}/Gt(ROSA)26Sor⁺; Malt1^{tm1c(EUCOMM)Hmgu}/Malt1^{tm1c(EUCOMM)Hmgu}; Tg(KRT5-cre)5132Jlj/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * DBA/2J

mortality/aging

mortality/aging ( J:292094 )

N • mice exhibit normal postnatal survival

Genotype
MGI:6460073

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CARD14*)Ribt}/Gt(ROSA)26Sor⁺; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1

mortality/aging

premature death ( J:292094 )

• in tamoxifen-treated mice

integument

increased keratinocyte proliferation ( J:292094 )

• in the basal layer of ear skin of tamoxifen-treated mice

skin inflammation ( J:292094 )

• reminiscent of Munros abscesses in the stratum corneum in tamoxifen-treated mice

hyperkeratosis ( J:292094 )

• in tamoxifen-treated mice

parakeratosis ( J:292094 )

• in tamoxifen-treated mice

acanthosis ( J:292094 )

• in tamoxifen-treated mice

thick epidermis ( J:292094 )

• in tamoxifen-treated mice

psoriasis ( J:292094 )

• from 6 weeks on, mice exhibit mild ear thickening unlike control mice

• tamoxifen-treated mice exhibit increased progressive ear swelling with ears becoming scaly and red unlike control mice

immune system

increased neutrophil cell number ( J:292094 )

• in the ear of tamoxifen-treated mice

increased dendritic cell number ( J:292094 )

• in the ear of tamoxifen-treated mice

skin inflammation ( J:292094 )

• reminiscent of Munros abscesses in the stratum corneum in tamoxifen-treated mice

growth/size/body

decreased body weight ( J:292094 )

• in tamoxifen-treated mice

homeostasis/metabolism

decreased circulating glucose level ( J:292094 )

• in tamoxifen-treated mice

cellular

increased keratinocyte proliferation ( J:292094 )

• in the basal layer of ear skin of tamoxifen-treated mice

hematopoietic system

increased neutrophil cell number ( J:292094 )

• in the ear of tamoxifen-treated mice

increased dendritic cell number ( J:292094 )

• in the ear of tamoxifen-treated mice

Genotype
MGI:6460074

cn4

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CARD14*)Ribt}/Gt(ROSA)26Sor⁺; Malt1^{tm1c(EUCOMM)Hmgu}/Malt1^{tm1c(EUCOMM)Hmgu}; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1

integument

skin inflammation ( J:292094 )

• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1

thick epidermis ( J:292094 )

• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1

psoriasis ( J:292094 )

• from 6 weeks on, mice exhibit mild ear thickening unlike control mice

• tamoxifen-treated mice exhibit increased ear swelling that is not as severe as in mice with wild-type Matl1

immune system

increased neutrophil cell number ( J:292094 )

• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1

increased dendritic cell number ( J:292094 )

• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1

skin inflammation ( J:292094 )

• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1

growth/size/body

decreased body weight ( J:292094 )

• in tamoxifen-treated that is not as severe as in mice with wild-type Matl1

hematopoietic system

increased neutrophil cell number ( J:292094 )

• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1

increased dendritic cell number ( J:292094 )

• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1