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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nell2em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6460272
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nell2em1Osb/Nell2em1Osb involves: C57BL/6NJcl * DBA/2NJcl MGI:6460304
cx2
 		Nell2em1Osb/Nell2em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6NJcl * DBA/2NJcl MGI:6460305
cx3
 		Nell2em1Osb/Nell2em1Osb
Tg(Clgn-Nell2)#Osb/0 		involves: C57BL/6NJcl * DBA/2NJcl MGI:6460306


Genotype
MGI:6460304
hm1
Allelic
Composition		 Nell2em1Osb/Nell2em1Osb
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nell2em1Osb mutation (2 available); any Nell2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal caput epididymis morphology ( J:290452 )
• impaired initial segment differentiation
epididymis degeneration ( J:335479 )
• degenerating initial segment
male infertility ( J:290452 )
• however, transgene expression of Nell2 rescues fertility




Genotype
MGI:6460305
cx2
Allelic
Composition		 Nell2em1Osb/Nell2em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nell2em1Osb mutation (2 available); any Nell2 mutation (46 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular

reproductive system




Genotype
MGI:6460306
cx3
Allelic
Composition		 Nell2em1Osb/Nell2em1Osb
Tg(Clgn-Nell2)#Osb/0
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nell2em1Osb mutation (2 available); any Nell2 mutation (46 available)
Tg(Clgn-Nell2)#Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:290452 )
N
• male mice exhibit normal fertility




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory