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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp628em1Frei
endonuclease-mediated mutation 1, Richard N Freiman
MGI:6460369
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zfp628em1Frei/Zfp628em1Frei involves: CD-1 MGI:6460370
ht2
 		Zfp628em1Frei/Zfp628+ involves: CD-1 MGI:6460372


Genotype
MGI:6460370
hm1
Allelic
Composition		 Zfp628em1Frei/Zfp628em1Frei
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp628em1Frei mutation (0 available); any Zfp628 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:292511 )
N
• females are fertile
azoospermia ( J:292511 )
• at P35 tubules are void of any mature sperm
abnormal acrosome morphology ( J:292511 )
• improperly formed acrosomal caps
multinucleated giant male germ cells ( J:292511 )
• several large multinucleated giant cells are present at P35
increased male germ cell apoptosis ( J:292511 )
• dramatic increase in the number of TUNEL positive cells in the tubules
small testis ( J:292511 )
• at P171 but not at P40
arrest of spermiogenesis ( J:292511 )
• arrest as stage VII round spermatids

endocrine/exocrine glands
small testis ( J:292511 )
• at P171 but not at P40

cellular
azoospermia ( J:292511 )
• at P35 tubules are void of any mature sperm
abnormal acrosome morphology ( J:292511 )
• improperly formed acrosomal caps
multinucleated giant male germ cells ( J:292511 )
• several large multinucleated giant cells are present at P35
increased male germ cell apoptosis ( J:292511 )
• dramatic increase in the number of TUNEL positive cells in the tubules




Genotype
MGI:6460372
ht2
Allelic
Composition		 Zfp628em1Frei/Zfp628+
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp628em1Frei mutation (0 available); any Zfp628 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased male germ cell number ( J:292511 )
• decrease in the number of germ cells at P35
• however, the full complement of differentiating germ calls is present
small testis ( J:292511 )
• at P171 but not at P40

endocrine/exocrine glands
small testis ( J:292511 )
• at P171 but not at P40

cellular
decreased male germ cell number ( J:292511 )
• decrease in the number of germ cells at P35
• however, the full complement of differentiating germ calls is present




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory