All Phenotypes Tgfbr3l<em2Djb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tgfbr3l^em2Djb
endonuclease-mediated mutation 2, Daniel J Bernard
MGI:6460397

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgfbr3l^em2Djb/Tgfbr3l^em2Djb	C57BL/6N-Tgfbr3l^em2Djb	MGI:6836745
cn2	Gnrhr^{tm1.1(cre)Uboe}/Gnrhr⁺ Tgfbr3^tm1.1Hlin/Tgfbr3^tm1.1Hlin Tgfbr3l^em2Djb/Tgfbr3l^em2Djb	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N	MGI:6836747

Allelic Composition	Tgfbr3l^em2Djb/Tgfbr3l^em2Djb
Genetic Background	C57BL/6N-Tgfbr3l^em2Djb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfbr3l^em2Djb mutation (0 available); any Tgfbr3l mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:316383 )

N	• female mice exhibit normal ovarian and uterine weights, hormone-stimulated superovulation, and serum levels of progesterone and luteinizing hormone

abnormal oocyte number ( J:316383 )

• increased egg production during the natural cycle

• however, response to hormone-stimulated egg release is normal

increased corpora lutea number ( J:316383 )

increased tertiary ovarian follicle number ( J:316383 )

• increased numbers of antral follicles

increased litter size ( J:316383 )

• from female mice

• however, litter frequency is normal

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:316383 )

• modest

cellular

abnormal oocyte number ( J:316383 )

• increased egg production during the natural cycle

• however, response to hormone-stimulated egg release is normal

endocrine/exocrine glands

increased corpora lutea number ( J:316383 )

increased tertiary ovarian follicle number ( J:316383 )

• increased numbers of antral follicles

Allelic Composition	Gnrhr^{tm1.1(cre)Uboe}/Gnrhr⁺ Tgfbr3^tm1.1Hlin/Tgfbr3^tm1.1Hlin Tgfbr3l^em2Djb/Tgfbr3l^em2Djb
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnrhr^{tm1.1(cre)Uboe} mutation (0 available); any Gnrhr mutation (20 available)
Tgfbr3l^em2Djb mutation (0 available); any Tgfbr3l mutation (20 available)
Tgfbr3^tm1.1Hlin mutation (0 available); any Tgfbr3 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased ovary weight ( J:316383 )

• more so than in Tgfbr3l^em2Djb homozygotes

growth/size/body

increased ovary weight ( J:316383 )

• more so than in Tgfbr3l^em2Djb homozygotes

homeostasis/metabolism

increased follicle stimulating hormone level ( J:316383 )

increased circulating follicle stimulating hormone level ( J:316383 )

• in the pituitary

reproductive system

increased ovary weight ( J:316383 )

• more so than in Tgfbr3l^em2Djb homozygotes

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