Phenotypes associated with this allele

• Allele Symbol: Adtrp^tm1.1Clu
• Allele Name: targeted mutation1.1, Cristina Lupu
• Allele ID: MGI:6460464
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adtrp^tm1.1Clu/Adtrp^tm1.1Clu	involves: 129S4/SvJaeSor * C57BL/6	MGI:6460471

Genotype
MGI:6460471

hm1

• Allelic Composition: Adtrp^tm1.1Clu/Adtrp^tm1.1Clu
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:295059 )

N • normal morphology of aorta and other large blood vessels at age P0

N • normal blood cell count (including platelets), thrombin-antithrombin complexes, prothrombin time, and activated partial thromboplastin time at age 2 months

abnormal vascular endothelial cell morphology ( J:295059 )

• heterogenous appearance of ECs at age P0

abnormal capillary branching pattern ( J:295059 )

• at age P0

dilated capillary ( J:295059 )

• at age P0

increased capillary tortuosity ( J:295059 )

• at age P0

abnormal perivascular vein cell coverage ( J:295059 )

• defective perivascular vein cell coverage at age P0

• extravasated red blood cells, neutrophils, and mast cells at age P0

hemorrhage ( J:295059 )

• microhemorrhages associated with low-pressure microvasculature such as postcapillary venules and small veins at age P0

• hemorrhage spots and extravascular fibrin deposition in skin, brain, heart, kidney, and lung at age P0

• hemorrhage spots and extravascular fibrin deposition in lung at age 3 months

cellular

abnormal extracellular matrix morphology ( J:295059 )

• degraded vascular ECM at age P0

abnormal basement membrane morphology ( J:295059 )

• distorted vascular BM at age P0

hematopoietic system

increased mast cell number ( J:295059 )

• accumulation of MCs in skin and tail coinciding with edema and extravasated red blood cells at age P0

homeostasis/metabolism

increased bleeding time ( J:295059 )

• significantly increased bleeding time and blood loss in tail at age 2 months

skin edema ( J:295059 )

• severe extravascular edema in skin and tail at age P0

immune system

increased mast cell number ( J:295059 )

• accumulation of MCs in skin and tail coinciding with edema and extravasated red blood cells at age P0

increased inflammatory response ( J:295059 )

• increased expression of inflammatory markers (Cxcl1, Itgam, Itgax, Lgals3, Cd4, Vcam1, Tnf) in cephalic skin at age P0

integument

skin edema ( J:295059 )

• severe extravascular edema in skin and tail at age P0

mortality/aging

perinatal lethality, incomplete penetrance ( J:295059 )

• 35% of pups stillborn or die peri- or neonatally

neonatal lethality, incomplete penetrance ( J:295059 )

• 35% of pups stillborn or die peri- or neonatally

prenatal lethality, incomplete penetrance ( J:295059 )

• 35% of pups stillborn or die peri- or neonatally