All Phenotypes 4930451I11Rik<em1Osb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

4930451I11Rik^em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6460465

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	4930451I11Rik^em1Osb/4930451I11Rik^em1Osb	involves: C57BL/6NJcl * DBA/2NJcl	MGI:6460468

Allelic Composition	4930451I11Rik^em1Osb/4930451I11Rik^em1Osb
Genetic Background	involves: C57BL/6NJcl * DBA/2NJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
4930451I11Rik^em1Osb mutation (2 available); any 4930451I11Rik mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:287619 )

N	• no gross abnormalities in testes morphology are detected

reduced male fertility ( J:287619 )

• males are severely subfertile with an average of 0.5 +/- 0.8 pups per plug compared to 8.5 +/- 1.7 for wild-type controls

impaired fertilization ( J:287619 )

• sperm penetrate the zona pellucida but rarely fertilize oocytes in vitro

• sperm show an impaired ability to fuse with zona pellucida free oocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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