Phenotypes associated with this allele

• Allele Symbol: Dynlrb1^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6466548
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dynlrb1^tm1c(EUCOMM)Wtsi/Dynlrb1^tm1c(EUCOMM)Wtsi	involves: 129S4/SvJaeSor * C57BL/6N	MGI:6466703
cn2	Dynlrb1^tm1c(EUCOMM)Wtsi/Dynlrb1^tm1c(EUCOMM)Wtsi Runx3^tm6(EGFP/cre)Yg/Runx3^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N	MGI:6466702

Genotype
MGI:6466703

cn1

• Allelic Composition: Dynlrb1^{tm1c(EUCOMM)Wtsi}/Dynlrb1^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N
• Cell Lines: EPD0373_7_C01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axonal transport ( J:292124 )

• after infection with Adenovirus 5 (Ad5) expressing a Cre-GFP, dorsal root ganglia (DRG) neurons transduced for 96 h in culture show impaired axonal retrograde transport of acidic organelles, including lysosomes, late endosomes and autophagosomes, both in terms of velocity of individual carriers and the overall fraction of moving carriers

Genotype
MGI:6466702

cn2

• Allelic Composition: Dynlrb1^{tm1c(EUCOMM)Wtsi}/Dynlrb1^{tm1c(EUCOMM)Wtsi}; Runx3^{tm6(EGFP/cre)Yg}/Runx3⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N
• Cell Lines: EPD0373_7_C01

behavior/neurological

limb grasping ( J:292124 )

• adult mice show an abnormal clenched hind-limb phenotype when suspended by the tail

abnormal motor coordination/balance ( J:292124 )

• adult mice exhibit impaired proprioception

impaired balance ( J:292124 )

• adult mice are unable to balance themselves on an accelerating rotarod

abnormal gait ( J:292124 )

• adult mice show an uncoordinated walking pattern with abdomen posture close to the ground and display an abnormal walking pattern in the catwalk

decreased locomotor activity ( J:292124 )

• adult mice exhibit reduced speed and less distance traveled than wild type controls in the open field

• however, basal motor activity is normal

nervous system

nervous system phenotype ( J:292124 )

N • mice show no significant alterations in neuromuscular junction size or numbers and in total (Tuj1 positive) or nociceptive (CGRP positive) skin innervation

abnormal proprioceptive neuron morphology ( J:292124 )

• the number of proprioceptive NFH-positive neurons in DRG ganglia is significantly decreased

• however, the number of CGRP-positive nociceptive neurons is normal