Phenotypes associated with this allele

• Allele Symbol: Impg2^em2Xjz
• Allele Name: endonuclease-mediated mutation 2, Xianjun Zhu
• Allele ID: MGI:6466713
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Impg2^em2Xjz/Impg2^em2Xjz	C57BL/6J-Impg2^em2Xjz	MGI:6466735

Genotype
MGI:6466735

hm1

• Allelic Composition: Impg2^em2Xjz/Impg2^em2Xjz
• Genetic Background: C57BL/6J-Impg2^em2Xjz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

astrocytosis ( J:295355 )

• astrogliosis in retina at age 6 months

retina cone cell degeneration ( J:295355 )

• increased apoptosis at age 6 months

retina rod cell degeneration ( J:295355 )

• increased apoptosis at age 6 months

vision/eye

retina cone cell degeneration ( J:295355 )

• increased apoptosis at age 6 months

retina rod cell degeneration ( J:295355 )

• increased apoptosis at age 6 months

thin retina outer nuclear layer ( J:295355 )

• increasing decrease of peripheral ONL thickness at ages 6 and 12 months

• normal thickness at age 1 month

retina degeneration ( J:295355 )

• pigment deposits and scattered patchy gray lesions of 11.5 disc diameter in retina at age 3 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 56		DOID:0110371	OMIM:613581	J:295355