Phenotypes associated with this allele

• Allele Symbol: Hsf2bp^em1Roka
• Allele Name: endonuclease-mediated mutation 1, Ronald Kanaar
• Allele ID: MGI:6467326
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsf2bp^em1Roka/Hsf2bp^em1Roka	C57BL/6JOlaHsd-Hsf2bp^em1Roka	MGI:6467361

Genotype
MGI:6467361

hm1

• Allelic Composition: Hsf2bp^em1Roka/Hsf2bp^em1Roka
• Genetic Background: C57BL/6JOlaHsd-Hsf2bp^em1Roka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:294372 )

♀N • normal female fertility and litter size

azoospermia ( J:294372 )

♂

abnormal spermatocyte morphology ( J:294372 )

♂

abnormal chromosomal synapsis ( J:294372 )

♂ • many instances in zygotene nuclei where only a few chromosome pairs synapsed

♂ • pachytene nuclei absent

abnormal male meiosis ( J:294372 )

♂

small testis ( J:294372 )

♂

male infertility ( J:294372 )

♂

endocrine/exocrine glands

small testis ( J:294372 )

♂

cellular

azoospermia ( J:294372 )

♂

abnormal spermatocyte morphology ( J:294372 )

♂

abnormal chromosomal synapsis ( J:294372 )

♂ • many instances in zygotene nuclei where only a few chromosome pairs synapsed

♂ • pachytene nuclei absent

abnormal male meiosis ( J:294372 )

♂

mortality/aging

prenatal lethality, incomplete penetrance ( J:294372 )

♂ • mice born at lower than expected Mendelian ratio