Phenotypes associated with this allele

• Allele Symbol: Otud3^em1Nju
• Allele Name: endonuclease-mediated mutation1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:6467362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otud3^em1Nju/Otud3^em1Nju	involves: C57BL/6N	MGI:6467383

Genotype
MGI:6467383

hm1

• Allelic Composition: Otud3^em1Nju/Otud3^em1Nju
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal chemokine secretion ( J:294274 )

• increased Cxcl10 expression in bone-marrow-derived macrophages (BMDMs) and mouse embryo fibroblasts (MEFs) after Sendai virus (SeV) or stomatitis virus (VSV) infection or 5-triphosphorylated RNA or poly(I:C) injection

• increased Cxcl10 and Ccl5 expression in macrophages after Sendai virus (SeV) infection

increased interferon-beta secretion ( J:294274 )

• increased Ifnb1 expression and secretion in macrophages after Sendai virus (SeV) infection

• increased Ifnb1 expression in macrophages after poly(I:C) injection

• Increased Ifnb1 expression in macrophages after stomatitis virus (VSV) infection

• increased Ifnb1 expression in bone-marrow-derived macrophages (BMDMs) and mouse embryo fibroblasts (MEFs) after Sendai virus (SeV) or stomatitis virus (VSV) infection or 5-triphosphorylated RNA or poly(I:C) injection

• increased Ifnb1 expression in lungs, liver and spleen after stomatitis virus (VSV) infection

decreased susceptibility to Riboviria infection ( J:294274 )

• increased virus clearance and decreased VSV mRNA and VSV-G protein expression after stomatitis virus (VSV) infection

• increased Cxcl10 and Ccl5 expression and Ifnb1 expression and secretion in macrophages after Sendai virus (SeV) infection

• increased Ifnb1 expression in macrophages after poly(I:C) injection

• Increased Ifnb1 expression in macrophages after stomatitis virus (VSV) infection

• increased Ifnb1, Cxcl10 and Isg15 expression in bone-marrow-derived macrophages (BMDMs) and mouse embryo fibroblasts (MEFs) after Sendai virus (SeV) or stomatitis virus (VSV) infection or 5-triphosphorylated RNA or poly(I:C) injection

• decreased VSV mRNA and VSV-G protein expression and virus titers in lungs, liver and spleen after stomatitis virus (VSV) infection

• lower immune cell infiltration and reduced injury in lungs after stomatitis virus (VSV) infection

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:294274 )

• reduced mortality levels after lethal stomatitis virus (VSV) infection

growth/size/body

growth/size/body region phenotype ( J:294274 )

N • normal size and no gross physiological abnormalities

behavior/neurological

behavior/neurological phenotype ( J:294274 )

N • no gross behavioral abnormalities

mortality/aging

mortality/aging ( J:294274 )

N • viable

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:294274 )

• reduced mortality levels after lethal stomatitis virus (VSV) infection