Phenotypes associated with this allele

• Allele Symbol: Spocd1^em1Doca
• Allele Name: endonuclease-mediated mutation 1, Donal O'Carroll
• Allele ID: MGI:6467407
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spocd1^em1Doca/Spocd1^em1Doca	involves: C57BL/6 * C57BL/6N * CBA	MGI:6468346

Genotype
MGI:6468346

hm1

• Allelic Composition: Spocd1^em1Doca/Spocd1^em1Doca
• Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:295943 )

♂

abnormal chromosomal synapsis ( J:295943 )

♂ • defective chromosome pairing in testes meiotic cells

increased testis apoptosis ( J:295943 )

♂

abnormal DNA methylation during gametogenesis ( J:295943 )

♂ • deficient de novo DNA methylation in spermatogonia of transposable elements regulated by piRNA pathway

abnormal seminiferous tubule morphology ( J:295943 )

♂ • spermatids absent

♂ • meiotic arrest at early pachytene stage

testicular atrophy ( J:295943 )

♂

testis degeneration ( J:295943 )

♂

male infertility ( J:295943 )

♂

endocrine/exocrine glands

increased testis apoptosis ( J:295943 )

♂

abnormal seminiferous tubule morphology ( J:295943 )

♂ • spermatids absent

♂ • meiotic arrest at early pachytene stage

testicular atrophy ( J:295943 )

♂

testis degeneration ( J:295943 )

♂

cellular

azoospermia ( J:295943 )

♂

abnormal chromosomal synapsis ( J:295943 )

♂ • defective chromosome pairing in testes meiotic cells

increased testis apoptosis ( J:295943 )

♂

abnormal DNA methylation during gametogenesis ( J:295943 )

♂ • deficient de novo DNA methylation in spermatogonia of transposable elements regulated by piRNA pathway