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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sppl3em1Pomz
endonuclease-mediated mutation 1, Joel L Pomerantz
MGI:6467468
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sppl3em1Pomz/Sppl3em1Pomz C57BL/6J-Sppl3em1Pomz MGI:6515790
cn2
 		Sppl3tm1Itl/Sppl3em1Pomz
Ncr1tm1.1(icre)Viv/Ncr1+ 		involves: 129S/SvEv * C57BL/6 * C57BL/6J MGI:6515792


Genotype
MGI:6515790
hm1
Allelic
Composition		 Sppl3em1Pomz/Sppl3em1Pomz
Genetic
Background		 C57BL/6J-Sppl3em1Pomz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sppl3em1Pomz mutation (0 available); any Sppl3 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:280182 )
• nearly all mice are dead by weaning age
neonatal lethality, incomplete penetrance ( J:280182 )
• although mice are born in expected Mendelian ratios, ~15 of mice die shortly after birth




Genotype
MGI:6515792
cn2
Allelic
Composition		 Sppl3tm1Itl/Sppl3em1Pomz
Ncr1tm1.1(icre)Viv/Ncr1+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncr1tm1.1(icre)Viv mutation (1 available); any Ncr1 mutation (40 available)
Sppl3em1Pomz mutation (0 available); any Sppl3 mutation (75 available)
Sppl3tm1Itl mutation (0 available); any Sppl3 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:280182 )
N
• mice are born in Mendelian ratios and survive without any overt phenotype

immune system
abnormal NK cell differentiation ( J:280182 )
• mice show a defect in NK cell maturation with a 1.8-fold reduction of CD27+CD11b+ NK cells in the bone marrow and a 3-fold loss of CD27+CD11b+ NK cells in spleen
increased immature NK cell number ( J:280182 )
• mice show a 1.4-fold increase in the number of immature CD27+CD11b- NK cells in bone marrow but no significant change in spleen
decreased NK cell number ( J:280182 )
• mice exhibit reduced numbers of peripheral NK cells with a 2.9-fold reduction of NK cell number in spleen
• however, NK cell number is normal in the bone marrow
decreased mature NK cell number ( J:280182 )
• mice show a 6-fold reduction of mature CD27-CD11b+ NK cells in spleen, and 3-fold loss of CD27-CD11b+ NK cells in the bone marrow

hematopoietic system
abnormal NK cell differentiation ( J:280182 )
• mice show a defect in NK cell maturation with a 1.8-fold reduction of CD27+CD11b+ NK cells in the bone marrow and a 3-fold loss of CD27+CD11b+ NK cells in spleen
increased immature NK cell number ( J:280182 )
• mice show a 1.4-fold increase in the number of immature CD27+CD11b- NK cells in bone marrow but no significant change in spleen
decreased NK cell number ( J:280182 )
• mice exhibit reduced numbers of peripheral NK cells with a 2.9-fold reduction of NK cell number in spleen
• however, NK cell number is normal in the bone marrow
decreased mature NK cell number ( J:280182 )
• mice show a 6-fold reduction of mature CD27-CD11b+ NK cells in spleen, and 3-fold loss of CD27-CD11b+ NK cells in the bone marrow




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory