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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Styk1tm1Twa
targeted mutation 1, Thierry Walzer
MGI:6467474
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Styk1tm1Twa/Styk1tm1Twa B6J.B6N-Styk1tm1Twa MGI:6507858
hm2
 		Styk1tm1Twa/Styk1tm1Twa C57BL/6N-Styk1tm1Twa MGI:6507854


Genotype
MGI:6507858
hm1
Allelic
Composition		 Styk1tm1Twa/Styk1tm1Twa
Genetic
Background		 B6J.B6N-Styk1tm1Twa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Styk1tm1Twa mutation (0 available); any Styk1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:277150 )
N
• no differences in NK cell development or in vitro NK-cell functions are observed in mutant mice relative to wild-type controls
• when challenged with mouse cytomegalovirus (MCMV) Smith strain, mice survive the infection and recover in terms of weight, with no differences in serum IFN-gamma levels at day 2 post-infection or in frequency of Ly49H positive NK cells in spleen at day 7 post-infection relative to MCMV-infected wild-type controls




Genotype
MGI:6507854
hm2
Allelic
Composition		 Styk1tm1Twa/Styk1tm1Twa
Genetic
Background		 C57BL/6N-Styk1tm1Twa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Styk1tm1Twa mutation (0 available); any Styk1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:277150 )
N
• despite specific expression of Styk1 in wild-type NK cells, ILC1 (liver type 1 innate lymphoid cells) and spleen NK1.1+ gamma-delta T cells, no differences in NK cell development or in vitro NK-cell functions are observed in mutant mice relative to wild-type controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory