Phenotypes associated with this allele

• Allele Symbol: Taf1a^em1(IMPC)Bay
• Allele Name: endonuclease-mediated mutation 1, Baylor College of Medicine
• Allele ID: MGI:6467480
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Taf1a^em1(IMPC)Bay/Taf1a^em1(IMPC)Bay	C57BL/6NJ-Taf1a^em1(IMPC)Bay/Mmmh	MGI:7719839
hm2	Taf1a^em1(IMPC)Bay/Taf1a^em1(IMPC)Bay	C57BL/6N-Taf1a^em1(IMPC)Bay/BayMmucd	MGI:7415105

Genotype
MGI:7719839

hm1

• Allelic Composition: Taf1a^em1(IMPC)Bay/Taf1a^em1(IMPC)Bay
• Genetic Background: C57BL/6NJ-Taf1a^em1(IMPC)Bay/Mmmh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Taf1a^em1(IMPC)Bay/Taf1a^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as morulas but not at E7.5. Embryos fail to hatch from the zona pellucida and die after 3 days in culture.

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at nearly normal Mendelian ratios at E3.5 (19% versus expected 25%, n=116) and appear as morulae; no homozygous embryos or excess resorption sites are observed at E7.5

embryo

failure of blastocyst formation ( J:279207 )

• in vitro, embryos fail to form blastocysts and are dead after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that embryos fail to hatch from the zona pellucida after 3 days in culture

Genotype
MGI:7415105

hm2

• Allelic Composition: Taf1a^em1(IMPC)Bay/Taf1a^em1(IMPC)Bay
• Genetic Background: C57BL/6N-Taf1a^em1(IMPC)Bay/BayMmucd

Data Sources

IMPC Data for Taf1a

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM