Phenotypes associated with this allele

• Allele Symbol: Ticrr^em1(IMPC)Bay
• Allele Name: endonuclease-mediated mutation 1, Baylor College of Medicine
• Allele ID: MGI:6467486
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ticrr^em1(IMPC)Bay/Ticrr^em1(IMPC)Bay	C57BL/6NJ-Ticrr^em1(IMPC)Bay/Mmnc	MGI:7719845
hm2	Ticrr^em1(IMPC)Bay/Ticrr^em1(IMPC)Bay	C57BL/6N-Ticrr^em1(IMPC)Bay/BayMmucd	MGI:7415122

Genotype
MGI:7719845

hm1

• Allelic Composition: Ticrr^em1(IMPC)Bay/Ticrr^em1(IMPC)Bay
• Genetic Background: C57BL/6NJ-Ticrr^em1(IMPC)Bay/Mmnc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ticrr^em1(IMPC)Bay/Ticrr^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as morulae but not at E7.5. Embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming outgrowths.

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E3.5 (7% versus expected 25%, n=30) and appear as morulae; no homozygous embryos or excess resorption sites are observed at E7.5

embryo

failure of blastocyst formation ( J:279207 )

• in vitro, embryos fail to form blastocysts and are dead after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, embryos fail to hatch from the zona pellucida after 3 days in culture

Genotype
MGI:7415122

hm2

• Allelic Composition: Ticrr^em1(IMPC)Bay/Ticrr^em1(IMPC)Bay
• Genetic Background: C57BL/6N-Ticrr^em1(IMPC)Bay/BayMmucd

Data Sources

IMPC Data for Ticrr

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM