Phenotypes associated with this allele

• Allele Symbol: Rab35^tm1.1Vha
• Allele Name: targeted mutation 1.1, Volker Haucke
• Allele ID: MGI:6467522
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rab35^tm1.1Vha/Rab35^tm1.1Vha Tg(CAG-cre/Esr1*)5Amc/0	involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * C57BL/6 * CBA	MGI:6467551
cn2	Rab35^tm1.1Vha/Rab35^tm1.1Vha Tg(Mpz-cre)26Mes/0	involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/NTac	MGI:6467549

Genotype
MGI:6467551

cn1

• Allelic Composition: Rab35^tm1.1Vha/Rab35^tm1.1Vha; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased astrocyte size ( J:294178 )

• larger in vitro cultured astrocytes after tamoxifen induction

Genotype
MGI:6467549

cn2

• Allelic Composition: Rab35^tm1.1Vha/Rab35^tm1.1Vha; Tg(Mpz-cre)26Mes/0
• Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/NTac

mortality/aging

mortality/aging ( J:294178 )

N • born at normal Mendelian ratio

nervous system

decreased myelin sheath thickness ( J:294178 )

• normal thickness in sciatic nerves and normal number of myelinated axons at age P20, P30 and P90

• reduced thickness in larger sciatic nerves (>5 micrometer diameter) at age P90

tomacula ( J:294178 )

• in sciatic nerves at age P90