Phenotypes associated with this allele

• Allele Symbol: Cfap97d1^em1Osb
• Allele Name: endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:6469464
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cfap97d1^em1Osb/Cfap97d1^em1Osb	involves: C57BL/6NJcl * DBA/2NJcl	MGI:6469466

Genotype
MGI:6469466

hm1

• Allelic Composition: Cfap97d1^em1Osb/Cfap97d1^em1Osb
• Genetic Background: involves: C57BL/6NJcl * DBA/2NJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:294173 )

♀ • female mice exhibit normal fertility

abnormal sperm axoneme morphology ( J:294173 )

♂ • frequent lack of microtubule doublet 4

asthenozoospermia ( J:294173 )

♂ • reduced curvilinear velocity and average path velocity with more asymmetrical waveform pattern and reduced beat frequency in the midpiece compared with wild-type sperm

♂ • however, straight-line velocity is normal

reduced male fertility ( J:294173 )

♂ • male mice sired fewer pups per litter with half of male mice infertile

impaired sperm penetration of zona pellucida ( J:294173 )

♂

cellular

abnormal sperm axoneme morphology ( J:294173 )

♂ • frequent lack of microtubule doublet 4

asthenozoospermia ( J:294173 )

♂ • reduced curvilinear velocity and average path velocity with more asymmetrical waveform pattern and reduced beat frequency in the midpiece compared with wild-type sperm

♂ • however, straight-line velocity is normal