Phenotypes associated with this allele

• Allele Symbol: Zbed3^tm1.1Lil
• Allele Name: targeted mutation 1.1, Lei Li
• Allele ID: MGI:6469491
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zbed3^tm1.1Lil/Zbed3^tm1.1Lil	Not Specified	MGI:6469632

Genotype
MGI:6469632

hm1

• Allelic Composition: Zbed3^tm1.1Lil/Zbed3^tm1.1Lil
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal fertility/fecundity ( J:296111 )

♂ • normal male fertility

decreased litter size ( J:296111 )

♀ • when mated with WT or heterozygous or homozygous KO males

♀ • reduced number of stage E2.5 morulae in uterus when mated with WT males

♀ • reduced number of stage E3.5 embryos with blastocoel in uterus when mated with WT males

♀ • normal number of stage E0.5 zygotes and E1.5 2-cell embryos in uterus when mated with WT males

cellular

maternal effect ( J:296111 )

♀ • decreased litter size owing to abnormal embryonic development when mated with WT or heterozygous or homozygous KO males

♀ • reduced number of stage E2.5 morulae in uterus when mated with WT males

♀ • reduced number of stage E3.5 embryos with blastocoel in uterus when mated with WT males

♀ • normal number of stage E0.5 zygotes and E1.5 2-cell embryos in uterus when mated with WT males

♀ • delayed embryonic development when cultured in vitro from 2-cell stage

♀ • increased percentage of asymmetrically divided 2-cell embryos (one blastomere larger than other)

♀ • disordered, loose, rough and long F-actin fibers around mitotic spindle in zygotes