Phenotypes associated with this allele

• Allele Symbol: Dpp3^{tm1d(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6469644
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dpp3^tm1d(EUCOMM)Hmgu/Dpp3^tm1d(EUCOMM)Hmgu	involves: BALB/c * C57BL/6 * C57BL/6J * C57BL/6N * SJL	MGI:6469712

Genotype
MGI:6469712

hm1

• Allelic Composition: Dpp3^{tm1d(EUCOMM)Hmgu}/Dpp3^{tm1d(EUCOMM)Hmgu}
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased osteoclast cell number ( J:294242 )

• increased osteoclast surface over bone surface ratio in lumbar spine at age 6 months

decreased length of long bones ( J:294242 )

• at age 6 months

• normal at age 2 months

decreased bone volume ( J:294242 )

• reduced bone volume over total volume ratio in lumbar spine at age 6 months, exacerbated in ovariectomized mice

• increased bone surface over bone volume ratio in lumbar spine at age 6 months, exacerbated in ovariectomized mice

• normal in lumbar spine at age 2 months

decreased osteoblast cell number ( J:294242 )

• reduced osteoblast surface over bone surface ratio in lumbar spine at age 6 months

increased bone trabecular spacing ( J:294242 )

• in lumbar spine at age 6 months, exacerbated in ovariectomized mice

• normal in lumbar spine at age 2 months

decreased trabecular bone thickness ( J:294242 )

• in lumbar spine at age 6 months, exacerbated in ovariectomized mice

• normal in lumbar spine at age 2 months

increased osteoid thickness ( J:294242 )

• increased thickness and area in lumbar spine at age 6 months

increased osteoid volume ( J:294242 )

• increased thickness and area in lumbar spine at age 6 months

decreased bone ossification ( J:294242 )

• reduced bone formation rate in lumbar spine at age 6 months

• reduced mineralized surface over bone surface ratio in lumbar spine at age 6 months

increased bone resorption ( J:294242 )

• at age 6 months

immune system

increased osteoclast cell number ( J:294242 )

• increased osteoclast surface over bone surface ratio in lumbar spine at age 6 months

abnormal interferon-gamma secretion ( J:294242 )

• increased expression of Ifng in bone marrow at age 6 months

increased interleukin-1 beta secretion ( J:294242 )

• increased expression of Il1b in bone marrow at age 6 months

increased interleukin-10 secretion ( J:294242 )

• increased expression of Il10 in bone marrow at age 6 months

increased interleukin-6 secretion ( J:294242 )

• increased expression of Il6 in bone marrow at age 6 months

increased tumor necrosis factor secretion ( J:294242 )

• increased expression of Tnf in bone marrow at age 6 months

hematopoietic system

increased bone marrow cell number ( J:294242 )

• at age 6 months

• normal at age 2 months

increased osteoclast cell number ( J:294242 )

• increased osteoclast surface over bone surface ratio in lumbar spine at age 6 months

growth/size/body

decreased body weight ( J:294242 )

• at age 6 months

• normal at age 2 months

decreased body length ( J:294242 )

• at age 6 months

• normal at age 2 months

cellular

decreased apoptosis ( J:294242 )

• in bone at age 6 months

mortality/aging

mortality/aging ( J:294242 )

N • mice born at expected Mendelian ratio

N • normal lifespan

reproductive system

reproductive system phenotype ( J:294242 )

N • fertile