Analysis Tools
mortality/aging
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• 1 surviving mice died shortly after weaning
• mice supplemented with inositol die of unknown causes before wild-type mice
|
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• all but one mice died prior to birth
• however, supplementation with inositol increases survival to weaning
|
behavior/neurological
| N |
• mice supplemented with inositol exhibit normal performance on a rotarod
|
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• in mice supplemented with inositol in dark- and light-box, forced-swim, Y-maze tests, and fear-conditioning test
• in males in a an open field
|
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• delayed onset and offset of free-running under constant dark in mice supplemented with inositol
|
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• in older mice supplemented with inositol when removed from their home cages and placed on the floor
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craniofacial
| N |
• mice supplemented with inositol exhibit normal craniofacial development
|
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• at E14.5
|
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• at E14.5, but not E10.5
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cleft palate
(
J:250420
)
|
• in one mouse
|
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• poorly developed
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growth/size/body
cleft palate
(
J:250420
)
|
• in one mouse
|
|
• poorly developed
|
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• at E18.5
|
digestive/alimentary system
cleft palate
(
J:250420
)
|
• in one mouse
|
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• poorly developed
|
nervous system
|
• in older mice supplemented with inositol when removed from their home cages and placed on the floor
|
exencephaly
(
J:250420
)
|
• in two mice
|
skeleton
|
• at E14.5
|
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• at E14.5, but not E10.5
|
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• in some mice
• however, mice supplemented with inositol exhibit normal rib cage
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