Phenotypes associated with this allele

• Allele Symbol: Rtp4^em#Xzs
• Allele Name: endonuclease-mediated mutation, Xin-zhuan Su
• Allele ID: MGI:6470099
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rtp4^em#Xzs/Rtp4^em#Xzs	involves: C57BL/6	MGI:6470110

Genotype
MGI:6470110

hm1

• Allelic Composition: Rtp4^em#Xzs/Rtp4^em#Xzs
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to parasitic infection ( J:293929 )

• increased serum IFNA and IFNB levels 1 day post-injection with P. yoelii malaria parasite strain N67-infected red blood cells or N67 and cGAMP

• increased spleen Ifna, Ifnb, Mx1 and Cxcl10 mRNA levels 1 day post-injection with P. yoelii malaria parasite strain N67-infected red blood cells and cGAMP

• reduced parasitemia at 6 days post-injection with different doses of P. yoelii malaria parasite strain N67-infected red blood cells

• normal serum IFNA and IFNB levels 4 days post-injection with P. yoelii malaria parasite strain N67-infected red blood cells

• normal survival rates after injection with P. yoelii malaria parasite strain N67-infected red blood cells

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:293929 )

• reduced parasitemia, lower simple neuroassessment of asymmetric impairment (SNAP) scores for cerebral malaria, and higher body weight between 5 and 8 days post-injection with of P. berghei malaria parasite strain ANKA-infected red blood cells

• longer survival after injection with of P. berghei malaria parasite strain ANKA-infected red blood cells

• reduced number of hemorrhagic foci in brain 6 days post-injection with of P. berghei malaria parasite strain ANKA-infected red blood cells

• increased Ifna and Ifnb mRNA levels in microglia after injection with of P. berghei malaria parasite strain ANKA-infected red blood cells

• normal pathology of spleen and liver 6 days post-injection with of P. berghei malaria parasite strain ANKA-infected red blood cells

decreased susceptibility to viral infection ( J:293929 )

• reduced brain viral load 7 days post-infection with West Nile Virus

• normal viral load in heart and spleen 7 days post-infection with West Nile Virus

growth/size/body

growth/size/body region phenotype ( J:293929 )

N • normal body weight

mortality/aging

mortality/aging ( J:293929 )

N • healthy

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:293929 )

• reduced parasitemia, lower simple neuroassessment of asymmetric impairment (SNAP) scores for cerebral malaria, and higher body weight between 5 and 8 days post-injection with of P. berghei malaria parasite strain ANKA-infected red blood cells

• longer survival after injection with of P. berghei malaria parasite strain ANKA-infected red blood cells

• reduced number of hemorrhagic foci in brain 6 days post-injection with of P. berghei malaria parasite strain ANKA-infected red blood cells

• increased Ifna and Ifnb mRNA levels in microglia after injection with of P. berghei malaria parasite strain ANKA-infected red blood cells

• normal pathology of spleen and liver 6 days post-injection with of P. berghei malaria parasite strain ANKA-infected red blood cells