Phenotypes associated with this allele

• Allele Symbol: Tg(Nphs1-ACE2)#Kdbu
• Allele Name: transgene insertion, Kevin D Burns
• Allele ID: MGI:6470404
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Nphs1-ACE2)#Kdbu/0	FVB//N-Tg(Nphs1-ACE2)#Kdbu	MGI:6470482

Genotype
MGI:6470482

tg1

• Allelic Composition: Tg(Nphs1-ACE2)#Kdbu/0
• Genetic Background: FVB//N-Tg(Nphs1-ACE2)#Kdbu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:198181 )

♂ • untreated mice show decreased body weight

homeostasis/metabolism

decreased circulating triglyceride level ( J:198181 )

♂ • STZ-treated mice show lower serum triglycerides than treated wild-type mice

abnormal susceptibility to non-insulin-dependent diabetes ( J:198181 )

♂ • mice show attenuation of the development of nephropathy in streptozotocin (STZ)-induced diabetes, showing a delay in the development of albuminuria, renal protection with an early reduction in mesangial expansion and attenuation of glomerular hypertrophy at 16 weeks, less pronounced podocyte loss and reduction in cortical TGFB1 expression at 8 weeks

♂ • however, STZ-treated mice develop diabetes and show similar elevations of plasma glucose, loss of body weight, kidney hypertrophy, glomerular hyperfiltration, and systolic blood pressure as wild-type mice

renal/urinary system

decreased podocyte number ( J:198181 )

♂ • podocyte numbers per glomerulus are lower in untreated mice