Analysis Tools
neoplasm
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• mice injected with the alkylating mutagen azoxymethane (AOM) and repetitively administered dextran sulfate sodium (DSS) show earlier appearance of colonic tumors that grow larger than in wild-type mice, with overall colonic tumor number and burden increased indicating accelerated progression of colitis-associated cancer
• however, aged mice do not develop spontaneous tumors in the GI tract
• mice treated with AOM and DSS to induce colitis-associated cancer show similar tumor epithelial proliferation and apoptosis as wild-type mice and a similar level of tumor-infiltrating CD45+ leukocytes
• following acute DSS challenge, mice show no changes in the influx of T cells or macrophages in the colonic lamina propria compared to wild-type mice
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digestive/alimentary system
| N |
• mice exhibit normal colonic crypt architecture and normal colonic epithelial cell proliferation and apoptosis
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• an increase in the ability of colon and small intestine epithelial single cells to generate colono-spheroids is seen, however no difference in the number of organoids formed is seen
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• mice exhibit accelerated progression of colitis-associated cancer following AOM and DSS treatment
• mice treated with DSS to induce colitis show altered colon mucin scaffolding network
• however, mice with DSS-induced colitis show no differences from wild-type mice in weight, colitis scores or colon lengths
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homeostasis/metabolism
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• mice injected with the alkylating mutagen azoxymethane (AOM) and repetitively administered dextran sulfate sodium (DSS) show earlier appearance of colonic tumors that grow larger than in wild-type mice, with overall colonic tumor number and burden increased indicating accelerated progression of colitis-associated cancer
• however, aged mice do not develop spontaneous tumors in the GI tract
• mice treated with AOM and DSS to induce colitis-associated cancer show similar tumor epithelial proliferation and apoptosis as wild-type mice and a similar level of tumor-infiltrating CD45+ leukocytes
• following acute DSS challenge, mice show no changes in the influx of T cells or macrophages in the colonic lamina propria compared to wild-type mice
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immune system
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• mice exhibit accelerated progression of colitis-associated cancer following AOM and DSS treatment
• mice treated with DSS to induce colitis show altered colon mucin scaffolding network
• however, mice with DSS-induced colitis show no differences from wild-type mice in weight, colitis scores or colon lengths
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normal phenotype
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• mice appear normal, exhibit normal reproductive behavior and produce normal litter sizes, show no obvious defects in the intestines or mammary development during pregnancy, and have normal hematopoietic cell subset composition and splenic dendritic cell development and apoptosis
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