All Phenotypes Tg(Myh6-cre)#Cya MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Myh6-cre)#Cya
transgene insertion, Cyagen Biosciences
MGI:6470610

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{em1(CAG-Zfas1)Cya}/Gt(ROSA)26Sor⁺ Tg(Myh6-cre)#Cya/0	involves: C57BL/6J	MGI:6470625

Allelic Composition	Gt(ROSA)26Sor^{em1(CAG-Zfas1)Cya}/Gt(ROSA)26Sor⁺ Tg(Myh6-cre)#Cya/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{em1(CAG-Zfas1)Cya} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Myh6-cre)#Cya mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated heart left ventricle ( J:294533 )

• increased left ventricular internal dimension at end-diastole (LVIDd) and at systole (LVIDs)

decreased cardiac muscle contractility ( J:294533 )

• decreased ejection fraction (EF) and fractional shortening (FS)

cellular

increased cardiomyocyte apoptosis ( J:294533 )

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:294533 )

• increased resting intracellular Ca²⁺ level in cardiomyocytes

muscle

decreased cardiac muscle contractility ( J:294533 )

• decreased ejection fraction (EF) and fractional shortening (FS)

increased cardiomyocyte apoptosis ( J:294533 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24