Phenotypes associated with this allele

• Allele Symbol: Gkap1^em1Feis
• Allele Name: endonuclease-mediated mutation 1, Fei Sun
• Allele ID: MGI:6470626
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gkap1^em1Feis/Gkap1^em1Feis	involves: C57BL/6	MGI:6470632

Genotype
MGI:6470632

hm1

• Allelic Composition: Gkap1^em1Feis/Gkap1^em1Feis
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:293924 )

♂N • normal reproductive performance

♂N • normal testis morphology

♂N • normal cauda sperm motility and progressive motility

abnormal spermatocyte morphology ( J:293924 )

♂ • decreased germ cell apoptosis at stages IIV and XIXII

♂ • normal germ cell apoptosis at stages V-X

♂ • increased number of midpachytene spermatocytes and round spermatids per Sertoli cells in stage VI-VIII tubules

♂ • normal number of preleptotene spermatocytes per Sertoli cells in stage VI-VIII tubules

abnormal testis morphology ( J:293924 )

♂N • decreased germ cell apoptosis at stages IIV and XIXII

♂N • normal germ cell apoptosis at stages V-X

increased testis weight ( J:293924 )

♂ • normal testis morphology

♂ • increased weight

increased sperm number ( J:293924 )

♂ • increased sperm count in testis and increased sperm concentration in whole epididymis

♂ • increased sperm count in female reproductive tract after mating

abnormal cauda epididymis morphology ( J:293924 )

♂ • larger tube

♂ • contains more sperm

enlarged corpus epididymis ( J:293924 )

♂ • larger tube

enlarged epididymis ( J:293924 )

♂ • normal caput and initial regions

♂ • increased cauda and corpus region size

increased epididymis weight ( J:293924 )

♂

endocrine/exocrine glands

abnormal testis morphology ( J:293924 )

♂N • decreased germ cell apoptosis at stages IIV and XIXII

♂N • normal germ cell apoptosis at stages V-X

increased testis weight ( J:293924 )

♂ • normal testis morphology

♂ • increased weight

cellular

abnormal spermatocyte morphology ( J:293924 )

♂ • decreased germ cell apoptosis at stages IIV and XIXII

♂ • normal germ cell apoptosis at stages V-X

♂ • increased number of midpachytene spermatocytes and round spermatids per Sertoli cells in stage VI-VIII tubules

♂ • normal number of preleptotene spermatocytes per Sertoli cells in stage VI-VIII tubules

growth/size/body

growth/size/body region phenotype ( J:293924 )

♂N • normal body weight