Phenotypes associated with this allele

• Allele Symbol: Pfkfb2^tm1.2Dap
• Allele Name: targeted mutation 1.2, David A Power
• Allele ID: MGI:6470720
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pfkfb2^tm1.2Dap/Pfkfb2^tm1.2Dap	involves: C57BL/6	MGI:6470721

Genotype
MGI:6470721

hm1

• Allelic Composition: Pfkfb2^tm1.2Dap/Pfkfb2^tm1.2Dap
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased blood urea nitrogen level ( J:296139 )

• decrease in plasma urea

increased kidney glycogen level ( J:296139 )

• mice in a model of folic acid nephropathy show a greater increase in glycogen accumulation in kidneys than in wild-type mice

• however, mice exposed to unilateral ureteric obstruction show a similar level of glycogen accumulation in kidneys as in wild-type mice

renal/urinary system

increased kidney glycogen level ( J:296139 )

• mice in a model of folic acid nephropathy show a greater increase in glycogen accumulation in kidneys than in wild-type mice

• however, mice exposed to unilateral ureteric obstruction show a similar level of glycogen accumulation in kidneys as in wild-type mice

small kidney ( J:296139 )

• however, kidneys appear histologically normal

renal fibrosis ( J:296139 )

• mice exposed to unilateral ureteric obstruction exhibit increased renal fibrosis compared to wild-type mice

• however, mice in a model of folic acid nephropathy show no difference in renal fibrosis compared to wild-type mice