Phenotypes associated with this allele

• Allele Symbol: Klhl18^lowf
• Allele Name: low frequency
• Allele ID: MGI:6470867
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klhl18^lowf/Klhl18^lowf	C57BL/6N-Klhl18^lowf	MGI:6771562

Genotype
MGI:6771562

hm1

• Allelic Composition: Klhl18^lowf/Klhl18^lowf
• Genetic Background: C57BL/6N-Klhl18^lowf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:311444 )

N • mice exhibit normal distortion product otoacoustic emission, endocochlear potential, cochlear microphonics, summating potentials, and innervation of the cochlea

abnormal inner hair cell stereociliary bundle morphology ( J:311444 )

• frequent tapering of the tallest stereocilia in the apical turn

increased or absent threshold for auditory brainstem response ( J:311444 )

• at 2 weeks, mice exhibit a slight increase in ABR threshold and abnormal ABR waveforms with smaller amplitudes compared to in wild-type mice

• at 3 weeks of age, mice exhibit smaller click-evoked response compared with wild-type mice

• progressive increase in threshold from 4 weeks of age onward with smaller click-evoked averaged waveforms compared with wild-type mice

• mice exhibit reduced ABR wave 1 amplitude and longer latency compared with wild-type mice

• however, tone-evoked ABR is normal at 3 weeks of age

abnormal cochlear nerve compound action potential ( J:311444 )

• increased latencies

nervous system

abnormal inner hair cell stereociliary bundle morphology ( J:311444 )

• frequent tapering of the tallest stereocilia in the apical turn

abnormal cochlear nerve compound action potential ( J:311444 )

• increased latencies