Phenotypes associated with this allele

• Allele Symbol: Pcgf1^tm1.1Hko
• Allele Name: targeted mutation 1.1, Haruhiko Koseki
• Allele ID: MGI:6470899
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pcgf1^tm1.1Hko/Pcgf1^tm1.1Hko Phox2b^em3(cre)Heno/Phox2b^+	involves: 129 * C57BL/6 * C57BL/6N * DBA	MGI:7736341

Genotype
MGI:7736341

cn1

• Allelic Composition: Pcgf1^tm1.1Hko/Pcgf1^tm1.1Hko; Phox2b^em3(cre)Heno/Phox2b⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6N * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:344865 )

• only half of mutants survive to adulthood

growth/size/body

decreased body size ( J:344865 )

• at 3 weeks of age

postnatal growth retardation ( J:344865 )

• at 3 weeks of age but catch up to controls (mice carrying just the recombinase allele) by 8 weeks of age

digestive/alimentary system

abnormal feces composition ( J:344865 )

• lighter and drier feces

decreased feces water content ( J:344865 )

abnormal colon morphology ( J:344865 )

• decrease in the number of the somatostatin-expressing neurons in the proximal colon

• increase in the number of calbindin-expressing neurons in the proximal colon

abnormal ileum morphology ( J:344865 )

• decrease in the number of the somatostatin-expressing neurons in the ileum

abnormal jejunum morphology ( J:344865 )

• decrease in the number of the somatostatin-expressing neurons in the jejunum

abnormal intestinal transit time ( J:344865 )

• increased total gastrointestinal transit time

nervous system

decreased neuron number ( J:344865 )

• decrease in the number of the somatostatin-expressing neurons in the ileum, jejunum, and proximal colon

increased neuron number ( J:344865 )

• increase in the number of calbindin-expressing neurons in the proximal colon