Phenotypes associated with this allele

• Allele Symbol: Prl7d1^em1Liga
• Allele Name: endonuclease-mediated mutation 1, Gang Li
• Allele ID: MGI:6470966
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prl7d1^em1Liga/Prl7d1^em1Liga	involves: C57BL/6	MGI:6470967

Genotype
MGI:6470967

hm1

• Allelic Composition: Prl7d1^em1Liga/Prl7d1^em1Liga
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:288761 )

N • in crosses between heterozygous mice the expected number of homozygous offspring are found

cellular

maternal effect ( J:288761 )

• decrease in the number of viable embryos at E12.5 and increase in aborted or reabsorbed embryos in crosses of homozygous mice

• however, when the maternal genotype is heterozygous, homozygous embryos are viable

• placental defects are seen when the maternal genotype is homozygous

embryo

abnormal placenta morphology ( J:288761 )

• ratio of the junctional zone to labyrinth layer is increased when the maternal genotype is homozygous

increased uterine NK cell number ( J:288761 )

• increase in the number of decidual NK cells in placentals when the maternal genotype is homozygous

abnormal uterine spiral artery morphology ( J:288761 )

♀ • impaired remodeling of maternal spiral arteries resulting in an increase in arterial luminal diameter and outer diameter

♀ • however, fetal vascular networks appear similar to controls

abnormal placenta junctional zone morphology ( J:288761 )

• expanded giant cells in the junctional zone when the maternal genotype is homozygous

increased trophoblast glycogen cell number ( J:288761 )

♂ • increased in the placenta at E12.5 in male but not female fetuses, when the maternal genotype is homozygous

decreased placenta weight ( J:288761 )

♂ • when the maternal genotype is homozygous the placental weight is reduced for male but not female fetuses at E12.5

reproductive system

increased uterine NK cell number ( J:288761 )

• increase in the number of decidual NK cells in placentals when the maternal genotype is homozygous

abnormal uterine spiral artery morphology ( J:288761 )

♀ • impaired remodeling of maternal spiral arteries resulting in an increase in arterial luminal diameter and outer diameter

♀ • however, fetal vascular networks appear similar to controls

decreased litter size ( J:288761 )

• decrease in litter sizes and decrease in the number of viable embryos at E12.5

immune system

increased uterine NK cell number ( J:288761 )

• increase in the number of decidual NK cells in placentals when the maternal genotype is homozygous

hematopoietic system

increased uterine NK cell number ( J:288761 )

• increase in the number of decidual NK cells in placentals when the maternal genotype is homozygous

endocrine/exocrine glands

increased uterine NK cell number ( J:288761 )

• increase in the number of decidual NK cells in placentals when the maternal genotype is homozygous