Phenotypes associated with this allele

• Allele Symbol: Abhd11^tm1Esco
• Allele Name: targeted mutation 1, Johanna Escoubet
• Allele ID: MGI:6471012
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abhd11^tm1Esco/Abhd11^tm1Esco	involves: C57BL/6	MGI:6471015

Genotype
MGI:6471015

hm1

• Allelic Composition: Abhd11^tm1Esco/Abhd11^tm1Esco
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:294591 )

♂ • slight but significant decrease in weight in males

decreased susceptibility to diet-induced obesity ( J:294591 )

• no difference in body weight on standard or high fat diets in either male or female mice

vision/eye

abnormal anterior uvea morphology ( J:294591 )

• melanophagy in the iris or the ciliary body

iris synechia ( J:294591 )

cataract ( J:294591 )

abnormal retina morphology ( J:294591 )

• retinal atrophy

blindness ( J:294591 )

• responses in vision and touch escape assays suggest ophthalmologic defects lead to blindness

homeostasis/metabolism

abnormal feces lipid level ( J:294591 )

• increase in fat content, including concentrations of free fatty acids, cholesterol and triglycerides, when on a high fat or standard diet

decreased susceptibility to diet-induced obesity ( J:294591 )

• no difference in body weight on standard or high fat diets in either male or female mice

decreased circulating glucose level ( J:294591 )

• on a high fat diet glucose levels do not increase unlike in diet matched wild-type controls

decreased circulating insulin level ( J:294591 )

• on a high fat diet insulin levels do not increase unlike in diet matched wild-type controls

improved glucose tolerance ( J:294591 )

• on a high fat diet glucose tolerance is not impaired unlike in diet matched wild-type controls

increased insulin sensitivity ( J:294591 )

• following insulin injection mice show a greater decrease in blood glucose at 30, 45, and 90 minutes post injection

digestive/alimentary system

abnormal feces lipid level ( J:294591 )

• increase in fat content, including concentrations of free fatty acids, cholesterol and triglycerides, when on a high fat or standard diet

increased defecation amount ( J:294591 )

• on a high fat diet

adipose tissue

decreased abdominal fat pad weight ( J:294591 )

♂ • in males

behavior/neurological

behavior/neurological phenotype ( J:294591 )

N • no difference in food intake is seen compared to wild type mice on either standard or high-fat diets