Phenotypes associated with this allele

• Allele Symbol: Hnrnpa2b1^tm1.1Caox
• Allele Name: targeted mutation 1.1, Xuetao Cao
• Allele ID: MGI:6471775
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hnrnpa2b1^tm1.1Caox/Hnrnpa2b1^tm1.1Caox Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd	MGI:6471819

Genotype
MGI:6471819

cn1

• Allelic Composition: Hnrnpa2b1^tm1.1Caox/Hnrnpa2b1^tm1.1Caox; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:283622 )

• mice infected with HSV-1 exhibit increased mortality compared to controls

immune system

immune system phenotype ( J:283622 )

N • mice show similar frequencies of F4/80+CD11b+ macrophages, natural killer cells, B cells, T cells, neutrophils, and monocytes in the spleen as in wild-type mice

abnormal interferon level ( J:283622 )

• peritoneal macrophages infected with vaccinia virus (VACV) induces IFNB1 production to a certain level after 4 hours but shows no subsequent increases as seen in wild-type peritoneal macrophages

• macrophages infected with vaccinia virus show lower and less sustained IFNB1 expression than wild-type macrophages

decreased circulating interferon-beta level ( J:283622 )

• HSV-1 challenged mice exhibit severely attenuated serum IFN-beta concentrations

• however, serum IL-6, IFN-beta, and TNF-alpha concentrations are similar to wild-type mice after RNA virus Sendai virus infection

decreased interferon-beta secretion ( J:283622 )

• HSV-1 infected peritoneal macrophages show decreased secretion of IFN-beta

increased susceptibility to Herpesvirales infection ( J:283622 )

• mice infected with herpes simplex type 1 virus (HSV-1) show much higher viral titers in the brain compared to infected controls

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:283622 )

• mice infected with HSV-1 exhibit increased mortality compared to controls

homeostasis/metabolism

abnormal interferon level ( J:283622 )

• peritoneal macrophages infected with vaccinia virus (VACV) induces IFNB1 production to a certain level after 4 hours but shows no subsequent increases as seen in wild-type peritoneal macrophages

• macrophages infected with vaccinia virus show lower and less sustained IFNB1 expression than wild-type macrophages

decreased circulating interferon-beta level ( J:283622 )

• HSV-1 challenged mice exhibit severely attenuated serum IFN-beta concentrations

• however, serum IL-6, IFN-beta, and TNF-alpha concentrations are similar to wild-type mice after RNA virus Sendai virus infection