Phenotypes associated with this allele

• Allele Symbol: Mafb^em1Hts
• Allele Name: endonuclease-mediated mutation 1, Hiroyasu Tsukaguchi
• Allele ID: MGI:6471912
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mafb^em1Hts/Mafb^em1Hts	involves: C57BL/6J	MGI:6471914
ht2	Mafb^em1Hts/Mafb^+	involves: C57BL/6J	MGI:6471918

Genotype
MGI:6471914

hm1

• Allelic Composition: Mafb^em1Hts/Mafb^em1Hts
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:296168 )

• newborns die within 48 hours after birth

renal/urinary system

abnormal podocyte morphology ( J:296168 )

• podocytes show incomplete differentiation with failure to project foot processes to the outer surface of the glomerular capillaries in neonates, indicating impaired podocyte maturation

abnormal podocyte foot process morphology ( J:296168 )

• arrangement of podocyte foot processes is distorted with nearly 100% showing a flattered pattern

abnormal renal glomerulus morphology ( J:296168 )

• glomeruli of neonates exhibit obliteration of capillary tufts lined with immature columnar-shaped podocytes

expanded mesangial matrix ( J:296168 )

Genotype
MGI:6471918

ht2

• Allelic Composition: Mafb^em1Hts/Mafb⁺
• Genetic Background: involves: C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:296168 )

• mice do not show any gross abnormalities, including no renal problems, up to 2 months of age