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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mecp2em1Jlzn
endonuclease-mediated mutation 1, Jeffrey Lorenz Neul
MGI:6472627
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
Mecp2em1Jlzn/Y C57BL/6-Mecp2em1Jlzn MGI:6472629


Genotype
MGI:6472629
ot1
Allelic
Composition
Mecp2em1Jlzn/Y
Genetic
Background
C57BL/6-Mecp2em1Jlzn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2em1Jlzn mutation (0 available); any Mecp2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• decrease in longevity
• however, mice show increased longevity compared with Mecp2tm1.1Irsf hemizygous mice

behavior/neurological
• mice show progressive increase in phenotypic severity but delayed onset of severe phenotypes compared with Mecp2tm1.1Irsf hemizygous mice
• mice show decreased freezing in contextual and cued fear conditioning tasks indicating deficits in hippocampal- and amygdala-dependent learning
• mice show decreased freezing in contextual and cued fear conditioning tasks indicating deficits in hippocampal- and amygdala-dependent learning
• mice exhibit decreased motor learning on the rotarod
• mice show increased preference for the center zone of the arena, suggesting reduced anxiety
• mice exhibit impaired motor function in the accelerating rotating rod task
• mice show impaired motor dysfunction on the forepaw wire hanging task, falling sooner off the wire compared to wild-type mice
• mice exhibit abnormal gait patterns showing decreased hind paw stride length and decreased longitudinal deviation
• decrease in hind paw stride length
• mice are hypoactive with decreased distance traveled in the open field arena
• 13-week old, but not 9-week old mice, show spontaneous seizure activity
• during handling, a subset of mice show absence seizure-like events

nervous system
• 13-week old, but not 9-week old mice, show spontaneous seizure activity
• during handling, a subset of mice show absence seizure-like events

respiratory system
• mice show increased breathing irregularity
• mice show increased basal breathing rate
• mice show elevated incidence of apneas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:296009





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory