Phenotypes associated with this allele

• Allele Symbol: Slc16a7^tm1.1Lupel
• Allele Name: targeted mutation 1.1, Luc Pellerin
• Allele ID: MGI:6473153
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Slc16a7^tm1.1Lupel/Slc16a7^tm1.1Lupel	C57BL/6J-Slc16a7^tm1.1Lupel	MGI:6473220

Genotype
MGI:6473220

cn1

• Allelic Composition: Slc16a7^tm1.1Lupel/Slc16a7^tm1.1Lupel
• Genetic Background: C57BL/6J-Slc16a7^tm1.1Lupel

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:296969 )

♂N • normal mobility and thigmotaxis in open field test introduction in mice with dorsal hippocampal neuron-specific knock-out

♂N • normal novel object recognition 90 minutes after introduction in mice with dorsal hippocampal neuron-specific knock-out

♂N • normal behavior in predator odor test and elevated plus-maze and Y-maze tests in mice with dorsal hippocampal neuron-specific knock-out

♂N • normal time scores for immobility, swimming and climbing in forced swimming test in mice with dorsal hippocampal neuron-specific knock-out

abnormal object recognition memory ( J:296969 )

♂ • impaired novel object recognition 24 hrs after introduction in mice with dorsal hippocampal neuron-specific knock-out

♂ • normal novel object recognition 90 minutes after introduction in mice with dorsal hippocampal neuron-specific knock-out

impaired long-term object recognition memory ( J:296969 )

♂ • impaired novel object recognition 24 hrs after introduction in mice with dorsal hippocampal neuron-specific knock-out

impaired spatial learning ( J:296969 )

♂ • impaired recall 7 days after Morris water maze test in mice with dorsal hippocampal neuron-specific knock-out

♂ • delay in time to find platform on days 2 and 3 of Morris water maze test in mice with dorsal hippocampal neuron-specific knock-out

♂ • normal time to find platform on days 4-6 of Morris water maze test in mice with dorsal hippocampal neuron-specific knock-out

nervous system

impaired neuron differentiation ( J:296969 )

♂ • impaired generation of immature neurons derived from adult neurogenesis, as determined by DCX positive cells in the dentate gyrus, in mice with dorsal hippocampal neuron-specific knock-out

argyrophilic inclusion bodies ( J:296969 )

♂ • more intense argyrophilic areas in the dentate gyrus in mice with dorsal hippocampal neuron-specific knock-out

cellular

impaired neuron differentiation ( J:296969 )

♂ • impaired generation of immature neurons derived from adult neurogenesis, as determined by DCX positive cells in the dentate gyrus, in mice with dorsal hippocampal neuron-specific knock-out